Rivastigmine modestly improves dementia associated with Parkinson's disease, but has important adverse effects
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چکیده
منابع مشابه
Rivastigmine modestly improves dementia associated with Parkinson's disease, but has important adverse effects.
Patients: 541 people over the age of 50 years diagnosed with Parkinson’s disease (PD; UK PD Society Brain Bank criteria) and mild to moderate PD related dementia (DSM-IV; Mini Mental State Examination (MMSE) score 10–24). Exclusion criteria were: non-PD neurodegeneration; unstable medical comorbidity, disability, or dementia not related to PD; active, uncontrolled seizures; prior major depressi...
متن کاملRivastigmine for dementia associated with Parkinson's disease.
BACKGROUND Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor rivastigmine in such patients. METHODS Patients in whom mild-to-moderate dementia developed at least 2 years after they received a clinical diagnosis of Parkinson's disease were randomly assigned to receive placebo or...
متن کاملRivastigmine for the treatment of dementia associated with Parkinson’s disease
Parkinson's disease (PD) afflicts millions of people worldwide and leads to cognitive impairment or dementia in the majority of patients over time. Parkinson's disease dementia (PDD) is characterized by deficits in attention, executive and visuospatial function, and memory. The clinical diagnostic criteria and neuropathology surrounding PDD remain controversial with evidence of overlap among PD...
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Rivastigmine is a carbamate-type dual inhibitor of brain acetyl- and butyrylcholinesterases that has been evaluated in the symptomatic treatment of patients with mild to moderate dementia associated with idiopathic Parkinson's disease. Oral rivastigmine 3-12 mg/day for 24 weeks was significantly more effective than placebo in ameliorating cognitive and functional decline, including attentional ...
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ژورنال
عنوان ژورنال: Evidence-Based Mental Health
سال: 2005
ISSN: 1362-0347
DOI: 10.1136/ebmh.8.2.41